The oral BTK inhibitor rilzabrutinib led to rapid and durable platelet responses, reduced bleeding, and improved fatigue in patients with previously treated immune thrombocytopenia.
Phase 3 data support rilzabrutinib as a potential first-in-class oral Bruton tyrosine kinase inhibitor for patients with previously treated
Briefing moderator Charles Abrams, MD, University of Pennsylvania, Philadelphia, noted that LUNA 3 enrolled a"remarkably tough group of patients, really the hardest of the hard" and showed that rilzabrutinib was"well-tolerated and caused an increase in platelet counts." "People living with immune thrombocytopenia who cannot tolerate or do not respond to medications aimed at raising platelet counts are at risk of uncontrolled bleeding and often endure side effects from steroids and other available therapies," Kuter noted in a Sanofi
Platelet response — defined as counts at or above 50,000/μL or counts between 30,000/μL and 50,000/μL but doubled from baseline — was achieved in nearly two thirds of patients taking rilzabrutinib compared with almost one third of patients taking placebo at week 13.
Platelet Count Thrombocyte Count Platelets Thrombocytes Platelet Count (PLT) Thromboembolism Immune Thrombocytopenia Fatigue Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Idiopathic Thrombocytopenic Purpura Immune Thrombocytopenic Purpura Pain Management Hematology Haematology Patient Safety Thrombocytopenic Purpura
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