Editorial: Revisiting checkpoint blockade
of which set the field alight in 2020 — does “not appear to be therapeutically relevant” in small-cell lung cancer.
Given the high attrition of ICI candidates, there was a buzz at ASCO around biomarkers that can optimize patient selection. A particularly impressive example is the use of high DNA microsatellite instability in aof an anti-PD-1 mAb used as a neoadjuvant in stage 2–3 rectal cancer; although the trial involved only 12 patients, every MSI-high patient responded, remaining in remission after up to two years.
Although MSI-high status is uncommon in cancers, immune biomarkers promise wider applicability. One ASCO presentation describing a retrospective analysis of patients undergoing PD-1/PD-L1 immunotherapy in lung cancer reported that low scores in an panel all relapsed within 45 days, whereas only a third of patients with high scores relapsed in three years. Similarly, an algorithm for classifyingwas reported to be effective at predicting anti-PD-1 mAb responders in a phase 2 trial of solid tumors . Combining this panel with measurements of circulating tumor DNA further improved predictive power. Several other markers —
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