Science, Space and Technology News 2024
Recent research shows that exercise can prevent or slow cognitive decline by affecting gene expression in the brain cells of mice. Exercise was found to revert aged microglia to a youthful state and is essential for new neuron formation in the hippocampus. Additionally, exercise reduced the presence of T cells in the aging brain. Credit: SciTechDaily.com
Exercise can rejuvenate brain immune cells and reduce aging effects, highlighting the need for tailored exercise programs to support cognitive health. provides insights into how exercise may help to prevent or slow cognitive decline during aging. For the study, investigators assessed the expression of genes in individual cells in the brains of mice. The team found that exercise has a significant impact on gene expression in microglia, the immune cells of the central nervous system that support brain function. Specifically, the group found that exercise reverts the gene expression patterns of aged microglia to patterns seen in young microglia.
The scientists also found that allowing mice access to a running wheel prevented and/or reduced the presence of T cells in the hippocampus during aging. These immune cells are not typically found in the brain during youth, but they increase with age.
“It highlights the importance of normalizing and facilitating access to tailored exercise programs. Our findings should help different industries to design interventions for elderly individuals who are looking to maintain or improve both their physical and mental capabilities.”SciTechDaily: Home of the best science and technology news since 1998. Keep up with the latest scitech news via email or social media.
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