The failure of phase 3 of the MOSAICO trial has led to outpourings of 'disappointment,' 'frustration,' 'sadness,' and 'pain' by the researchers and participants involved.
BUENOS AIRES — The failure of phase 3 of the MOSAICO trial has led to outpourings of"disappointment,""frustration,""sadness," and"pain" by the researchers and participants involved. The trial tested the efficacy and safety of a preventive regimen of two vaccines againstin more than 50 sites in eight countries, including Spain, Argentina, Mexico, Peru, and Brazil.
"But there must be a vaccine; this must not be our last attempt at finding it. Even though we have very good and effective [HIV] treatment and prevention strategies, the search for a vaccine must remain a top priority," added Crabtree Ramírez.
According to data presented January 25 at a webinar, volunteers from Ibero-America made up almost 90% of participants: Peru , Brazil , Argentina , Mexico and Spain . The rest were recruited in Italy, Poland, and the United States . The last volunteer to complete the regimen did so this past October.
"HIV is characterized by evading the immune response and very effectively concealing itself from the immune system. In this sense, the search for a vaccine is extremely complex if we compare it with other viruses, such as SARS-CoV-2," said Marcelo Losso, MD, head of thepatient department at the Ramos Mejía Hospital Sexual Health Clinic in Buenos Aires, which recruited 127 participants for the trial.
For the time being, Wallace has ruled out the possibility that access to PrEP could have affected the results of the trial. At 24 months, only 10% of participants reported having resorted to PrEP.
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