Scientists led by Professor Claudia Höbartner at the University of Würzburg have revealed the 3D structure of SAMURI, a lab-generated RNA enzyme. This discovery provides insights into the development of ribozymes and the evolution of catalytically active RNA. SAMURI's unique ability to chemically modify other RNA molecules at specific sites and influence their function makes it a valuable subject of study.
Researchers have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and the evolution of catalytically active RNA.
A group of researchers led by Professor Claudia Höbartner at the University of Würburg has now uncovered the three-dimensional structure of a very special ribozyme: SAMURI. This is an RNA molecule generated in the lab that the team first presented in 2023.
Thanks to the deciphered molecular structure of SAMURI, the researchers can now better answer the question of how the specific interaction of artificial ribozymes with SAM differ from natural riboswitches. Studies suggest that naturally occurring SAM-binding RNA could be derived from earlier ribozymes that lost their catalytic function during evolution," says Höbartner.
RNA ENZYMES RIBOZYMES EVOLUTION MOLECULAR STRUCTURE CHEMICAL MODIFICATIONS
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