A new human monoclonal antibody moves a step closer to a universal antibody cocktail that works against all strains of SARS-CoV-2.
SARS-CoV-2, the virus that causes COVID-19 disease, continues to evolve and evade current vaccine and therapeutic interventions. A consortium of scientists at Texas Biomedical Research Institute , the University of Alabama at Birmingham and Columbia University have developed a promising new human monoclonal antibody that appears a step closer to a universal antibody cocktail that works against all strains of SARS-CoV-2.
While existing antibody treatments have helped many patients with COVID-19, some treatments have been rendered infective because the virus evolved and the antibodies could no longer physically bind to the targeted region -- in other words, the key no longer fit the lock. The monoclonal antibody is designed based on antibodies the UAB team isolated from patients infected with the Omicron variant of SARS-CoV-2. The teams at Texas Biomed and Columbia University tested the antibody against several variants including the original SARS-CoV-2 isolated in China, Omicron JN.1 and SARS-CoV.
The consortium of scientists has filed a provisional invention patent for 1301B7 and is in the process of licensing it for commercialization.
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