An international research collaboration, led by Prof. Dr. Robert Grosse (Centre for Integrative Biological Signalling Studies and Institute of Clinical and Experimental Pharmacology and Toxicology, University of Freiburg), Dr. Libor Macurek (Institute of Molecular Genetics, Czech Academy of Sciences, Prague) and Dr.
Albert-Ludwigs-Universität FreiburgJul 16 2024 An international research collaboration, led by Prof. Dr. Robert Grosse , Dr. Libor Macurek and Dr. Zdenek Lansky has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.
The crucial role of FAM110A in the proper formation of spindle actin Precise segregation of the genetic information into daughter cells is essential in all tissues of our bodies. This process needs to be tightly regulated in space and time to prevent developmental abnormalities. It has been known for decades that chromosomes attach to a bipolar structure called mitotic spindle that is composed of so-called microtubules.
Until recently, scientists believed that actin filaments are needed only for the final step of daughter cell separation and the role of actin cytoskeleton in mitosis has long been neglected. In their latest study, the research team now demonstrates that the previously unexplored protein FAM110A has unique properties that enable it to bind actin and microtubules at opposite ends, specifically at the poles of the mitotic spindles.
Actin Biotechnology Cancer Cell Cell Division Cytoskeleton Genetic Genetics Mitosis Pharmacology Research Toxicology
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