UC San Diego researchers have uncovered how pancreatic cancer stem cells use a protein from a family of proteins that typically suppresses tumors to instead enhance their resistance to standard treatments and promote growth. Pancreatic cancer is a highly deadly form of cancer, ranking third in th
Pancreatic cancer cells are shown growing as a sphere encased in membranes . Credit: National Cancer Institute
Previous research has shown that pancreatic cancer treatment resistance is caused by differing responses to conventional agents, fueled by the heterogeneity of tumor cells — and in particular, stem cell characteristics that encourage therapy resistance. “We wanted to identify the underlying tools and mechanisms that cancer stem cells use to better understand treatment resistance — and perhaps how they might be circumvented.”
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