Researchers have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. The new approach offers a clearer window than current drug methods used to understand cell cycle arrest -- a fundamental mechanism that is key to treating cancers and genetic issues.
Researchers at Colorado State University have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. The new approach offers a clearer window than current drug methods used to understand cell cycle arrest -- a fundamental mechanism that is key to treating cancers and genetic issues.and were led at CSU by Assistant Professor Grant Schauer in the Department of Biochemistry and Molecular Biology.
"Our work shows that hydroxyurea is stopping this replication process in a less specific way than anyone had originally thought," he said."We found that oxidation was inhibiting DNA polymerases -- the enzymatic machines that directly copy the DNA -- by targeting iron atoms in the enzymes and making them apart. Something that persisted even after the drug was removed from the process.
Hannah Reitman, an undergraduate biochemistry student, served as an author on the paper after collecting and analyzing data for the project. She said work in the lab was intimidating at first but became a great learning experience. "RNR-deg yeast strain seems to be a very viable and potentially superior alternative," he said."It does not have any of the negative effects of hydroxyurea that have likely been clouding our understanding to this point. This is an important finding, and I look forward to continuing our research towards use in human cells in the future."Alisa E. Shaw, Mattias N. Mihelich, Jackson E. Whitted, Hannah J. Reitman, Adam J. Timmerman, Muhammad Tehseen, Samir M. Hamdan, Grant D.
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