Though exceedingly rare, some people diagnosed with amyotrophic lateral sclerosis (ALS) partially or fully recover from the lethal neurodegenerative disease.
Duke University Medical CenterJul 30 2024 Though exceedingly rare, some people diagnosed with amyotrophic lateral sclerosis partially or fully recover from the lethal neurodegenerative disease .
"With other neurological diseases, there are now effective treatments," said Richard Bedlack, M.D., Ph.D., the Stewart, Hughes, and Wendt Professor in the Department of Neurology at Duke University School of Medicine. "But we still don't have great options for these patients, and we desperately need to find things. This work provides a starting point to explore how biological reversals of ALS occur and how we might be able to harness that effect therapeutically.
Evadnie Rampersaud, Ph.D., co-lead author, St. Jude Children's Research Hospital Center for Applied Bioinformatics Related StoriesIGF-1 is a growth factor that has long been a target of interest in ALS research because of its role in protecting the motor neurons. ALS patients with fast progression of disease have lower levels of IGF-1 protein, but clinical trials aimed at raising their IGF-1 levels have had disappointing results."This suggests that the IGF-1 pathway should be further studied as a potential target for future ALS treatments," Crayle said.
Amyotrophic Lateral Sclerosis Children Genome Hospital Motor Neurons Neurodegenerative Disease Neurology Neurons Ph Protein Research Sclerosis
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