Researchers have identified a potential biomarker of Parkinson's disease progression. According to the new study, patients with a slow progression of the pathology would have a significant increase in the levels of a molecule called ecto-GPR37 in the cerebrospinal fluid.
Researchers have identified a potential biomarker of Parkinson's disease progression. According to the new study, patients with a slow progression of the pathology would have a significant increase in the levels of a molecule called ecto-GPR37 in the cerebrospinal fluid.
According to the researcher, patients with rapid progression have an accelerated onset and worsening of symptoms, motor fluctuations and complications, as well as an increased likelihood of cognitive impairment and psychiatric symptoms. In contrast, patients with slow progression have a gradual onset and progression of symptoms and can maintain higher levels of functional ability and for longer periods of time. In addition, they often have milder symptoms, especially in the early stages.
The results of this analysis show that ecto-GPR37 levels were only increased in patients with slowly progressive Parkinson's disease, and not in the fast type or in the other pathologies."This finding suggests a possible connection between the processing and expression of GPR37 and the speed of disease progression," says Francisco Ciruela.
Moreover, the researchers, thanks to funding from the Michael J. Fox Foundation, have recently adapted an assay to determine the presence of ecto-GPR37 in blood samples from patients,"which makes it much easier to determine analytically," they conclude.Josep Argerich, Leonardo D. Garma, Marc López-Cano, Paula Álvarez-Montoya, Laura Gómez-Acero, Víctor Fernández-Dueñas, Ana B.
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