A new mechanism of aging has been uncovered by researchers: the accumulation of sphingolipids. Ceramides, a widely known class of sphingolipids, build up in aging muscle and reduce its function, impacting the functional capacity of older adults. These findings inspire the development of potential dr
in Switzerland discovered that ceramides, a class of fat molecules known as sphingolipids, begin to accumulate in muscle during aging and hinder its function. Ceramides play a vital role in skin protection and are commonly found in skin care products. Despite their skin benefits, the impact of ceramides on aging has remained unclear until now.
“The link between sphingolipids and aging and its related diseases is a broad and fascinating subject, as they mediate a range of tasks in cells, including cell division and differentiation as well assignaling,” says Pirkka-Pekka Laurila, MD, from the University of Helsinki and École Polytechnique Fédérale de Lausanne.
Usually, the number of stem cells in muscles decreases as we get older. “We found that when ceramide production was inhibited, the number of muscle stem cells and their functional capacity was better preserved,” says Professor Johan Auwerx from École Polytechnique Fédérale de Lausanne. “These older adults with a genetic mechanism for reducing ceramide synthesis in muscle tissue were fitter for their age, as manifested by increased handgrip strength and ability to walk long distances and stand up from a chair.
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