Researchers may have just stumbled upon a new way to take on brain tumours after finally figuring out why people with asthma are less likely to develop this form of cancer healthing - via healthing_ca
Dave Yasvinski,The suspicion that inflammatory diseases are related to a reduced risk of brain tumours was first proposed around 15 years ago. GETTY
, the senior author of the study. “But what if we could trick the T cells into thinking they’re asthma T cells when they enter the brain, so they no longer support brain tumour formation and growth? These findings open the door to new kinds of therapies targeting T cells and their interactions with cells in the brain.”
Gutmann began to notice an inverse relationship between the two conditions around five years ago through his study of neurofibromatosis — a set of complex genetic disorders that leads to the growth of tumours on nerves in the brain and throughout the body. He wasn’t sure what to make of the connection until more recent research in his lab identified the key role immune cells play in the formation of tumours on the optic pathways of children with NF type 1.
Further study revealed that the T cells of these mice began to behave differently after developing asthma, secreting a protein called decorin that is known to act on and irritate the lining of the airways. In the brain, however, this protein produces a very different result, blocking the activation of immune cells called microglia that promote tumour growth.
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