Harnessing a pervasive type of cellular messenger shows early experimental promise as a routine way of sampling and monitoring the body's response to prescription drug exposure.
Harnessing a pervasive type of cellular messenger shows early experimental promise as a routine way of sampling and monitoring the body's response to prescription drug exposure. Experiments have successfully isolated drug-metabolizing enzymes from extracellular vesicles , which are widely secreted throughout the body for cellular communication.
Tao and his associates have begun developing a patent-pending EV method for detecting proteins involved in drug absorption, distribution, metabolism and excretion ."If successful, this would be tremendously beneficial, especially for drug development companies," Tao said. Standard practice may dictate that a typical person should take two pills of a given medicine daily. But the response and effectiveness could vary greatly depending on the individual, Tao noted, adding,"And we don't have a good way to monitor it."
The PNAS Nexus paper notes that"in clinical scenarios, real-time ADME protein detection still lacks effective analytical methods for precise drug efficacy and toxicity evaluation for each patient." Analyzing EVs from blood samples for drug metabolism presents challenges because the EVs the samples contain could have come from many different organs. The researchers would prefer to see EVs that were mostly secreted from liver cells, but those account for only a small percentage of blood samples.
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