An international team has found a new RNA virus that they believe is hitching a ride with a common human parasite. The virus is associated with severe inflammation in humans infected with the parasite Toxoplasma gondii, leading the team to hypothesize that it exacerbates toxoplasmosis disease.
An international team led by researchers at the University of Toronto has found a new RNA virus that they believe is hitching a ride with a common human parasite., along with 18 others that are closely related to it, was discovered through a computational screen of human neuron data -- an effort aimed at elucidating the connection between RNA viruses and neuroinflammatory disease.
Symptoms of toxoplasmosis can be aggravated by a hyperactivated human immune response. The virus-carrying parasite triggers this type of response when the immune system senses the foreign RNA of the virus. Zoonotic viruses that infect other living things in our environment in order to reach us are expected to cause the majority of emerging infectious diseases in humans, Babaian noted."This study underscores the importance of looking beyond the viruses that infect humans directly into the extended virome," he said.Purav Gupta, Aiden Hiller, Jawad Chowdhury, Declan Lim, Dillon Yee Lim, Jeroen P J Saeij, Artem Babaian, Felipe Rodriguez, Luke Pereira, Alejandro Morales-Tapia.
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