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This image shows a graph of gene expression patterns of organoids created in a University of Montana lab transitioning to become cells that form human cartilage. It’s overlaid on a picture of an organoid showing distinct outer and inner layers. Credit: Courtesy of Mark Grimes
“The cells that normally give rise to this type of cartilage are called neural crest cells,” Grimes said. “We found a novel method for generating craniofacial organoids from neural crest cells.” To accomplish this, the team used extensive analysis of biological markers and machine-learning pattern-recognition techniques to understand the cell signaling pathways involved when cells differentiate into cartilage.
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