A Japanese and French research team has developed a technique for connecting lab-grown brain-imitating tissue in a way that resembles circuits in our brains.
A Japanese and French research team has developed a technique for connecting lab-grown brain-imitating tissue. The most interesting part is that it has been done in a way that resembles circuits in our brains.It is challenging to study the exact mechanisms of brain development and functions. For example, brain cells grown in the lab tend to lack the characteristic connections of cells in the human brain.
Scientists from The University of Tokyo have discovered a way to make better connections between lab-grown “neural organoids.” These special tissues are created in experiments where human stem cells are grown into 3D structures to mimic brain development. They connected these organoids using axonal bundles, which are like bridges connecting different areas in a living human brain.
The cerebral organoids that were connected with axonal bundles showed more complex activity than single organoids. So the team stimulated the axonal bundles using a technique known as optogenetics. The organoid activity was altered accordingly and the organoids were affected by these changes. That lasted for some time and in a process that is known as plasticity. For example, plasticity is important because it helps researchers understand how brain-like structures respond and adapt to changes.
Brain Lab-Grown Tissue Neural Organoids Brain Development Brain Functions
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