Researchers have identified a new method of activating specific molecules to target cancer cells while leaving healthy cells unharmed. Using click-release proteolysis targeting chimeras, researchers have developed a new method of activating specific molecules to target only cancer cells.
Researchers from the University of Arizona Cancer Center have identified a new method of activating specific molecules to target cancer cells while leaving healthy cells unharmed., Wei Wang, PhD, and his team developed a new strategy called click-release proteolysis targeting chimeras, or crPROTACs, that allows for the activation and release of PROTACs only in cancer cells.
PROTACs are molecules that scientists designed to break down specific proteins in the body. They are now explored as a potential treatment for cancer; however, one of the challenges is that they can be harmful to healthy cells due to uncontrolled protein breakdown. "Unlike many other drug delivery strategies, this approach will be very precise in targeting just the tumor," Wang said.
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