Immunotherapies for cancer aim to induce the immune system to combat cancer cells more effectively.
Aug 25 2023Reviewed by Lily Ramsey, LLM In the journal Angewandte Chemie, a Chinese research team has now described a new, modular strategy for T-cell-based immunotherapy that manages to work without complex genetic modifications. Modulation of cell-cell communications through an ingenious regulatory circuit using various small, specially folded DNA molecules causes cancer cells to directly activate their mortal enemies, T cells.
The team at Hunan University, Hangzhou Institute of Medicine, the Chinese Academy of Sciences, and Shanghai Jiao Tong University is working on ways to close these loopholes. Their goal is to establish new cellular interactions without having to produce genetically modified immune cells or receptors. The idea is to produce a “short circuit” in the communication pathways, by which the T cells are activated directly by the tumor cells, avoiding the detour through APCs.
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