The role of epigenetics — heritable phenotypic changes that don’t alter DNA sequencing — is emerging as a potential marker and target in the diagnosis and management of obstructive sleep apnea.
In 2018, when the study of potentially modifiable genetic markers for sleep apnea was emerging, a group of researchers from Mexico published a study titled, “
“This is an area of growing interest, with work being done across the globe to better understand the interplay between epigenetics and obstructive sleep apnea,” said Anita Shelgikar, MD, a professor of neurology at the University of Michigan Medical School in Ann Arbor, Michigan, and a spokesperson for the American Academy of Sleep Medicine, regarding epigenetics.
The role of hypoxia-mediated epigenetic regulation in cancer, pulmonary hypertension, adaptation to high altitudes, and cardiorenal disease has drawn much attention, he added. Cortese isn’t alone in his research into the role of epigenetics in sleep disorders. Cheung and her colleagues at The George Washington University have. “Pediatric OSA increases the risk of cardiovascular, metabolic, and endothelial disease susceptibility in adulthood, specifically diseases such as obesity, hypertension, diabetes, and heart failure,” Cheung said.
Sleep Apnoea Genomics Genomic Medicine Epigenetics Sleep Disturbance Abnormal Sleep Pattern Sleep Disorder Somnipathy Sleep Obstructive Sleep Apnea Obstructive Sleep Apnea Syndrome Obstructive Sleep Apnoea Obstructive Sleep Apnoea Syndrome Children Child Childhood Pediatrics Kids Obesity Obese Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA
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