Reprogramming tumour-associated macrophages to outcompete cancer cells - Nature

Nature research paper: Reprogramming tumour-associated macrophages to outcompete cancer cells

. A schematic diagram showing two modes of mTORC1 signaling in TAMs promoted or suppressed by Rag GTPases. Under a normal protein diet condition, abundant cytosolic amino acids suppress the GATOR1 complex, but activate the FLCN complex, and induce Rag GTPases in a RagA/Bstate that recruits mTORC1 and TFEB/TFE3 to the Rag GTPase complex, supporting or inhibiting their activation, respectively.

mice were transferred into lethally irradiated MYC-PyMT recipients with a tumor burden around 250-350 mm

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