Reproductive impact of changes in the vaginal microbiome of obese women imperialcollege microbiome vaginalmicrobiome BV DV microbiota obese womenshealth
By Dr. Liji Thomas, MDJul 5 2023Reviewed by Aimee Molineux A recent study published in the Best Practice & Research Clinical Obstetrics and Gynecology Journal explored the impact of obesity on vaginal microbiota and reproduction.
Introduction The vaginal microbiota contains bacteria, viruses, and fungi, which exist in harmony with the rest of the cells and the extracellular environment within the human body. It is relatively homogeneous compared to other microbiota in humans, dominated by Lactobacillus species. Mechanistically, vaginal dysbiosis may be responsible for such outcomes by directly or indirectly producing metabolites that disrupt key cellular pathways relating to DNA repair, cell proliferation, apoptosis, and the immune response.
While the effects of obesity may involve psychological, inflammatory, hormonal, and immunological changes in such individuals, the current paper explored the impact of obesity on the vaginal microbiota and reproduction. With obesity, there is a marked shift in the gut microbiota, with a higher ratio of Firmicutes to Bacteroidetes, and increases in the abundance of certain species, including Lactobacillus. The resulting change in gut-derived metabolites adds to the alteration in the gut-brain crosstalk and may lead to weight gain.
They are also more likely to have the vaginal microbiota type found in women who suffered a miscarriage. How does this happen? The underlying mechanisms of vaginal dysbiosis in obesity are hypothetical at this point. Vaginal dysbiosis is a known risk factor for adverse reproductive outcomes. In women with recurrent pregnancy loss, the vaginal microbiota is more likely to be characterized by reduced L. crispatus and higher Gardnerella vaginalis abundance, reducing the level of protection against preterm birth.
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