Renal interferon-inducible protein 16 (IFI16) expression is associated with enhanced disease activity and worse prognosis in lupus nephritis (LN), finds a study in Arthritis Research & Therapy. IFI16 can be a biomarker to develop precise therapy for LN.
]. Endocapillary hypercellularity, neutrophils/karyorrhexis, fibrinoid necrosis, hyaline deposits, cellular-fibrocellular crescents, and interstitial inflammation were all activity indices. Total glomerulosclerosis score, fibrous crescents, tubular atrophy, and interstitial fibrosis were all considered chronicity indices.
For of renal outcome endpoints, conversion of anti-dsDNA antibodies from positive to negative and a ≥ 30% reduction from baseline estimated glomerular filtration rate were included. Serum creatinine level was used to calculate GFR according to the Chronic Kidney Disease Epidemiology Collaboration eGFR equation [Formalin-fixed paraffin-embedded renal sections from LN patients, disease controls and normal controls were deparaffinized in xylene and ethanol then rehydrated in graded ethanol.
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