The father of cancer immunotherapy, Steven A. Rosenberg, reflects on the patients who inspired his groundbreaking research.
Widely considered the father of cancer immunotherapy, Steven A. Rosenberg, MD, PhD, FAACR, has spent nearly 50 years analyzing the link between patients' immune reaction and their cancer response.His pioneering research established interleukin-2 as the first U.S. Food and Drug Administration–approved cancer immunotherapy in 1992.Dr.
That showed me that, in fact, if you could stimulate a strong enough immune reaction, in this case, an reaction, against foreign tissues from a different individual, that you could make large vascularized, invasive cancers disappear based on immune reactivities. Those were clues that led me toward studying the immune system's impact on cancer.As chief of the surgery branch at NIH, I began doing research. It was very difficult to manipulate immune cells in the laboratory.
In 1988, we demonstrated for the first time that transfer of lymphocytes with antitumor activity could cause the regression of melanoma. This was a living drug obtained from melanoma deposits that could be grown outside the body and then readministered to the patient under suitable conditions. Interestingly, . A company developed it to the point where in multi-institutional studies, they reproduced our results.
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