A new study suggests that impaired cardiac baroreflex sensitivity, a mechanism that helps regulate blood pressure, increases the risk of dementia and death in older adults not taking blood pressure medications.
Impairment in cardiac baroreflex sensitivity , which helps regulate blood pressure , is associated with an increased risk for dementia and mortality in older adults not taking antihypertensive medications.Researchers conducted a prospective cohort study to assess the association between cardiac baroreflex sensitivity and the risk for dementia and death in 1819 older adults (women, 62.6%; mean age, 71 years).
Baroreflex sensitivity was determined from 5-minute beat-to-beat blood pressure recordings at supine rest; it measured the correlation between changes in systolic blood pressure and subsequent heartbeat interval responses, with higher values indicating superior baroreflex sensitivity.The use of antihypertensive medications was reported by 32% of participants. The primary outcome was incident all-cause dementia, and the secondary outcome was all-cause mortality.Overall, 421 participants developed dementia in the study, with 324 being diagnosed with Alzheimer’s disease. The association between reduced baroreflex sensitivity and an increased risk for dementia varied significantly with respect to the use of antihypertensive medications (for interaction=.03) and was significant only in participants not taking antihypertensive medication (adjusted hazard ratio , 1.60;Reduced baroreflex sensitivity also was associated with an increased risk for all-cause mortality in those not taking antihypertensive medication (aHR, 1.76;The association between baroreflex sensitivity and risk for dementia remained significant after adjusting for systolic blood pressure, variability in beat-to-beat systolic blood pressure, and arterial stiffness.Baroflex sensitivity “may serve as a novel biomarker and potential therapeutic target for the early detection and prevention of dementia in older adults,” the authors of the study wrote. Monitoring baroreceptor function, which declines with age, “could be of particular clinical relevance in older adults,” they adde
Dementia Mortality Baroreflex Sensitivity Blood Pressure Older Adults
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