The most common presenting signs and symptoms of early-onset colorectal cancer include rectal bleeding, abdominal pain, and altered bowel habits, a new analysis found.
Patients with early-onset colorectal cancer often present with hematochezia or abdominal pain , symptoms frequently overlooked in younger populations, leading to delays in diagnosis of 4-6 months, a new analysis showed.As the number of cases of EOCRC, defined as colorectal cancer diagnosed before age 50, continues to rise, early detection has become increasingly important.
In a systematic review and meta-analysis of 81 studies with 24.9 million EOCRC cases, researchers sought to determine the most common presenting signs and symptoms, their association with EOCRC risk, and the time from presentation to diagnosis. Data extraction and quality assessment were performed independently in duplicate using PRISMA guidelines, and Joanna Briggs Institute critical appraisal tools were used to measure the risk of bias.Hematochezia was the most common presenting sign/symptom, with a pooled prevalence of 45%, followed by abdominal pain, with a pooled prevalence of 40%.
Altered bowel habits, which included constipation, diarrhea, and alternating bowel habits, were the third most common presenting sign/symptom , followed by unexplained weight loss . The likelihood of EOCRC was estimated to be fivefold to 54-fold higher with hematochezia and 1.3-fold to sixfold higher with abdominal pain."These findings and the increasing risk of CRC in individuals younger than 50 years highlight the urgent need to educate clinicians and patients about these signs and symptoms to ensure that diagnostic workup and resolution are not delayed.
Colorectal Cancer (CRC) Abdominal Pain Pain Management Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Abdominal Pain Genomics Genomic Medicine Hematochezia Rectal Bleeding Rectal Hemorrhage California Clinical Guidelines Guidelines Constipation Costiveness Diarrhea Diarrhoea Genetics Meta-Analysis Triage Weight Loss Weight Management
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