Mitochondria organelles came from primordial bacterial endosymbionts and still preserve distinct genes for important functions like making ATP.
To speed the emerging therapeutic research into the transfer of mitochondria between cells, 31 researchers have developed consensus recommendations for common terminology that describes mitochondria transfer and transplantation.
"Over the past few years, we have come to understand that mitochondria can be transferred from one cell to another, and that isolated mitochondria can be transplanted like an organ transplant," said Keshav K. Singh, Ph.D., professor in the University of Alabama at Birmingham Department of Genetics."Though the origins of mitochondria transfer are unclear, it has been observed in evolutionarily diverse eukaryotes, including yeast, mollusks, fish and rodents, as well as human cells.
The recommendations also review therapeutic approaches of mitochondria transplantation, including the definition of transplants; the types, durability, degree of engraftment and heterogeneity of transplants; cell engineering using extracellular mitochondria; and drugs that affect mitochondria transfer.
Amyotrophic Lateral Sclerosis Lymphoma Stem Cells Lung Cancer Cancer Sickle Cell Anemia Immune System
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