A 25-year-old woman presented with an irritated growth on the left buttock of 6 months’ duration. The lesion had grown slowly over time and became irritated because of the constant rubbing on her clothing due to its location.
Common histologic mimics of superficial angiomyxoma include aggressive angiomyxoma and angiomyofibroblastoma.It is thought that these 3 distinct tumor entities may arise from a common pluripotent cell of origin located near connective tissue vasculature, which may contribute to the similarities observed between them.
Cutaneous mucinoses encompass a diverse group of connective tissue disorders characterized by accumulation of mucin in the skin. Solitary focal cutaneous mucinoses are individual isolated lesions of mucin deposits that are unassociated with systemic conditions.Conversely, multiple FCMs presenting with multiple cutaneous lesions also have been described in association with systemic diseases such as scleroderma, systemic lupus erythematosus, and thyroid disease.
Another important differential diagnosis to consider is myxofibrosarcoma, a rare and malignant myxoid cutaneous tumor. Clinically, it presents asymptomatically as an indolent, slow-growing nodule on the limbs and limb girdles.Histopathologic features demonstrate a multilobular tumor composed of a mixture of hypocellular and hypercellular regions with incomplete fibrous septae . The presence of curvilinear vasculature is characteristic.
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