Artificial intelligence has transformed research into proteins and promises new drugs and materials.
The Light Gas Gun at the University of Kent is an unwieldy device which, to me, looks more like a lathe than a gun.
We are herded out of the gun room and after a quick countdown the gun operator, Luke Alesbrook, pushes the button, triggering the gun. When the stress is released the bundles snap back into their original position, kind of like a spring.Prof Ben Goult worked out the structure of talin and how it responds to forces and, with his colleague Prof Jennifer Hiscock, they came up with the idea of making talin into a shock-absorbing material.
"It wasn't easy. It took a team of six of us over four years to work out the protein structure of talin, and another four years to work out how talin responded to force" he says.Proteins are made up of chains of amino acids; unravelling those chains is a challenge A key event came in November 2020, when AlphaFold performed best at CASP 14, an assessment every two years where different computer programs predict the structure of proteins.
Thanks to AlphaFold and its offspring the database of protein structures has gone from a few hundred thousand to hundreds of millions.
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