Promoting Nanoparticle Delivery at 'Cellular Level' to Advance Nanomedicine: nanomedicine bionanotechnology nanoparticles nanotechnology nanoscience AdvSciNews
By Bhavna KavetiAug 2 2022Reviewed by Susha Cheriyedath, M.Sc. Spatiotemporal delivery of nanoparticles at the cellular level is desirable in nanomedicine to deliver a maximum cytotoxic drug into cancer cells via the accumulation of the nanoparticles in tumors. Nevertheless, the cancer-associated fibroblasts and macrophages in tumor cells reduce the efficiency of nanoparticle delivery in the spatiotemporal region.
Along with improving the penetration of these nanoparticle delivery systems into tumor cells, this therapy also helped in LTX accumulation in cancer cells and refurbished the immunosuppressive microenvironment to combine PD-1 blockade therapy. Moreover, the biodistribution of the designed nanoparticle delivery systems could be analyzed by quantifying their in vivo biodistribution between different cells.
Related StoriesWith the increasing importance of nanomedicine in cancer therapy, many nanoparticle delivery systems have been approved by the United States Food and Drug Administration . Specifically, spatiotemporal nanoparticle delivery systems were applied to cancer treatment, and their therapeutic efficiency depends on the biodistribution of agents in spatial and temporal regions in tumor cells.
To this end, various nanoparticle delivery systems based on liposomes, polymeric nanoparticles, polymeric micelles, polymer-drug conjugate nanoparticles, and lipid-drug conjugate nanoparticles have been developed to date. While a few of these are under preclinical or clinical trials, others are on the market.
Moreover, to observe the changes of cumulative drugs at the cellular level, a sophisticated method was established, wherein matrix-assisted laser desorption/ionization mass spectrometry imaging , flow cytometry and cell sorting , and confocal laser scanning microscopy technologies were used to quantify the amount of drug delivered in target cells.
Conclusion Overall, nanoparticle delivery systems, unlike conventional therapeutics, have the advantage of easy designing and tuning to reach the target site, not only to treat cancer but many other diseases. The GSH pulse therapy developed in the present study enables the reduction-sensitive nanoparticles to deliver the drugs to spatiotemporal regions of cancer cells that could synergize PD1 blockade therapy.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Nanoparticles' toxic effects on macrophagesNanoparticles' toxic effects on macrophages Nanoparticles macrophages Nanotoxicity Cytotoxicity Toxicity Cellularinternalization ElsevierNews
Read more »
Plasmonic Nanoparticles Prevent Poor Photovoltaic PerformancePlasmonic Nanoparticles Prevent Poor Photovoltaic Performance: solarcells nanoparticles NPs nanomaterials nanoscience nanotechnology SolarPower SolarEnergy
Read more »
Grimsby Town lose star player player to Championship side - but he's back on loanGrimsby Town lose star player to Championship side – but he’s back on loan officialgtfc
Read more »
James Maddison : Revised level of second Newcastle United bid after further briefing - ReportsJames Maddison : Revised level of second Newcastle United bid after further briefing - Reports nufc
Read more »
New petition calls for State Pension minimum pay of £200 each week for allThe petition proposes disregarding National Insurance Contributions record which determines the level of State Pension award.
Read more »
'Another Wembley scam!' German media claim England 'cheated' in Euro 2022 finalA German newspaper have claimed the Euro 2022 runners-up were ‘scammed’ during England’s historic victory at Wembley after not being awarded a penalty for a ‘clear handball’ 🧐
Read more »