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Research identifies the SH2B1 gene’s critical role in obesity through its impact on brain function and energy regulation, offering promising therapeutic potential for obesity management without the side effects of current drugs like Ozempic.
Obesity is a complex condition influenced by genetics, the food environment, behavior, and other factors. Historically, securing enough food to survive was challenging, but today, for most people, it’s as simple as opening a refrigerator.mutations in people are associated with obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease, formerly known as non-alcoholic fatty liver disease.
A study conducted by Rui and the team identifies where this gene is acting inside the brain, an area called the paraventricular hypothalamus, or PVH, which is involved in regulating blood pressure and fluid balance. One theory, Rui notes, is that the inflammation associated with weight gain can negatively affect this pathway in an indirect way, weakening the signals to stop eating., from the fruit fly to humans,” said Rui.
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