How inflammation affects braindevelopment Hudson_Research
]. However, the relationship between EEG and abnormal development of the neuronal microstructure is poorly understood. Thus, in the present study we tested the hypothesis that progressive antenatal inflammation induced by repeated, increasing-dose infusions of Gramnegative LPS would be associated with cortical inflammation and altered neuronal microstructural development.
Ewes were housed together in separate pens in a temperature controlled room with a 12-h light–dark cycle with access to food and water ad libitum. Four to five days of post-operative recovery were allowed before experiments commenced. Ewes and fetuses received daily i.v. infusions of ampicillin and engemycin for three consecutive days after surgery. Catheters were maintained patent with a continuous infusion of heparinised saline at a rate of .
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