Patients with paediatric-onset IBD and concomitant primary sclerosing cholangitis have substantially worse outcomes, with elevated risks for cancer and death.
affected the disease prognosis, with nearly a 28-fold higher risk for cancer and a 13-fold higher risk for mortality seen among patients with IBD and PSC than among the general population.Researchers assessed the impact of concomitant PSC on the prognosis of paediatric-onset IBD in a retrospective study analysing children diagnosed with IBD before 17 years of age and radiologically and/or histologically proven PSC from a population‐based IBD registry in northern France .
They included 24 patients with IBD and PSC and 96 propensity score-matched control patients with IBD . Mortality, cancer occurrence, intestinal resection, and treatment exposure were assessed among patients with IBD with and without PSC, with a median follow-up duration of 7 years for the IBD-PSC group and 6.3 years for the matched IBD group.Patients in the IBD-PSC group showed a 13.3-fold higher risk for mortality than the general population .
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our
IBD Inflammatory Bowel Disease (IBD) UK Site Content United Kingdom Site Content United Kingdom UK Children Child Childhood Pediatrics Kids Primary Sclerosing Cholangitis Primary Sclerosing Cholangitis (PSC) Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cholangitis Biliary Disease Gallbladder Disease Prognosis Anti-TNF Anti-Tumor Necrosis Factor Anti-Tumour Necrosis Factor Corticosteroids Surgery Cancer Risk Adolescent Medicine Teens Teenage Teenager Adolescent Health Adolescents Adolescent Colon Cancer Malignant Neoplasm Of The Colon Malignant Neoplasm Of The Large Intestine Hepatocellular Carcinoma HCC - Hepatocellular Carcinoma Liver Cancer HCC Hepatocellular Cancer Cancer Of The Liver Liver Carcinoma Carcinoma Of The Liver Immunosuppressive Therapy Immunosuppressive Agents Immunosuppressive Drugs
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Is Oral Vancomycin Effective for Paediatric IBD?Oral vancomycin is effective in achieving clinical and biochemical remission in paediatric patients with non-primary sclerosing cholangitis inflammatory bowel disease.
Read more »
Diet Rich in Ultraprocessed Grains Ups Risk for IBDPackaged breads and refined grain products may increase the odds of developing IBD, while minimally processed fresh bread and rice may offer some protection, a large analysis hints.
Read more »
IBD Linked to Higher Risk for Interstitial Lung DiseasePatients with IBD have a higher risk for interstitial lung disease than the general population, with the risk being more pronounced among women.
Read more »
Sleep Changes in IBD Could Signal Inflammation, FlareupsChanges in sleep metrics detected with wearable technology could serve as an inflammation marker and potentially predict IBD flareups, regardless of symptoms.
Read more »
Caution Needed in Prescribing IBD Meds in CKDManaging IBD in patients with CKD requires an individualized, stage-adjusted dosing strategy with vigilant renal monitoring, particularly in those with more advanced stages of renal disease.
Read more »
Maple Heights football: Mustangs’ secondary is primary strength — 2025 camp tourThe trio of Kindall Brown, Keshawn Sheppard and Na’Cari Gay are all college bound after one more season at Maple Heights.
Read more »