Science, Space and Technology News 2023
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Dr Emma Magavern, lead author and clinical doctor and researcher at the Queen Mary University of London said: “Clopidogrel has been shown to prevent heart attacks mainly in people of European ancestry. For the first time, we show that genetic variants that render clopidogrel ineffective are present at much higher rates in British people of Bangladeshi and Pakistani ancestry and are linked with a higher risk of having another heart attack in people prescribed clopidogrel.
British peoples of South Asian ancestry suffer from high rates of cardiovascular disease and therefore have both a high risk of needing an antiplatelet medication and a high risk of treatment failure with clopidogrel. This study also illustrates how systemic under-representation of South Asians in therapeutics trials has obscured the intersection of risks impacting this community.”
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