Study: New tool twice as accurate at predicting antibody resistance among US children with Kawasakidisease
The Kobayashi score is the most widely used tool for predicting intravenous immunoglobulin resistance in Kawasaki disease . The KS has shown good sensitivity and specificity in Japanese children; however, its use is limited outside of Japan. No models accurately predict IVIG resistance of children with KD in the United States. We sought to develop and test a novel scoring system to predict IVIG resistance in hospitalized children with KD.
The new score was then compared with the KS and performance characteristics were determined.A total of 208 subjects were reviewed. White blood cell count, neutrophil percentage, age, and serum albumin were used in the new score with equal weighting. Overall, the new score achieved improved sensitivity and similar specificity compared with the KS in predicting IVIG resistance in hospitalized children diagnosed with KD.Predicting IVIG resistance in children diagnosed with KD remains challenging.
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