Precise, pragmatic and inclusive: the modern era of oncology clinical trials - Nature Medicine

Innovative trial designs with a patient-centered mission are crucial to advancing modern cancer care - as demonstrated in the recent adaptive umbrella study CTONG1702. Read the News and Views from Sarah Goldberg and Michael Grant YaleMed

‘Lung adenocarcinoma’, formerly a solitary entity in the histology-based categorization of non–small-cell lung cancer , now represents an ever-expanding list of diseases defined by molecular drivers.

. Targeted therapeutics for this disease have seen variable success, with the antibody–drug conjugate trastuzumab deruxtecan and various others, such as the tyrosine kinase inhibitor pyrotinib, demonstrating promising efficacy in early-phase trials

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