Precise and Scarless DNA Editing: New CRISPR Method Enables Unmatched Efficiency

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Precise and Scarless DNA Editing: New CRISPR Method Enables Unmatched Efficiency
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The SEED/Harvest method enhances CRISPR-Cas9 technology to enable precise, efficient genomic edits in fruit flies, opening new possibilities for genetics and medical research.

Prof. Markus Affolter’s team at the Biozentrum, University of Basel, has now developed a new method called SEED/Harvest in the fruit fly . This method combines the CRISPR-Cas9 technique with the Single-Strand Annealing repair pathway, enabling genome-wide changes to be carried out more efficiently and without leaving unwanted scars. The study has been published in Developmental Cell.The SEED/Harvest method proceeds in two steps.

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