A discovery may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.
A discovery may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells , which produce all the body's different blood cells.
"It's normal for a tiny fraction of HSCs to exit the bone marrow and enter the blood stream, but what controls this mobilization isn't well understood," said Dr. Will, associate professor of oncology and of medicine, and the Diane and Arthur B. Belfer Faculty Scholar in Cancer Research at Einstein, and the co-leader of the Stem Cell and Cancer Biology research program at MECCC.
The researchers intend to continue their investigation into this process:"Our ongoing efforts will look for other functions of trogocytosis in HSCs, including potential roles in blood regeneration, eliminating defective stem cells and in hematologic malignancies," added Dr. Will.
Leukemia Osteoporosis Medical Topics Lung Cancer Lymphoma Immune System Prostate Cancer
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