+34Job description APPLICATION CLOSING DATE: February 16th, 2024 Human Technopole (HT) is a new interdisciplinary life science research institute created and supported by the Italian government, aimed at developing innovative solutions.
is a new interdisciplinary life science research institute created and supported by the Italian government, aimed at developing innovative solutions.operates at the intersection of biology, machine learning, statistics, and information theory.
Our goal is to comprehend and predict how genomic alterations and molecular traits, derived from various omics, contribute to pathological processes, rewire biological circuits, and influence therapeutic responses in human cancers and other diseases., funding the DepSHOCK project. The project focuses on identifying robust transcriptional markers of cancer cell vulnerabilities. These markers will be used together with single-cell transcriptomic profiling of cancer models, to advance personalised medicine and the rational design of anti-cancer combinatorial therapies., this project will generate post-perturbational transcriptomic datasets at both bulk and single-cell resolution, upon individual CRISPR-based genetic knockouts of relevant cancer dependency genes in associated dependent cancer in vitro models, as well as in a pooled fashion, using scale-limited libraries of single-guide RNAs. We are actively seeking a post-doctoral fellow to play a key role in the DepSHOCK project. The selected candidate will be an integral part of the team generating and analysing data across the project’s work packages. They will closely interact with the DepSHOCK lab technician and computational postdoc, mainly performing wet laboratories activities but also using bioinformatics packages and software tools for basic computational tasks. Additionally, the hired candidate will provide support for the experimental validation of the identified markers, working closely with our external collaborators. HT benefits from accessibility to the HT National Facility for Genomics, providing state-of-the-art and innovative services ranging from high-throughput sequencing to multi-omics technologies.Contributing to the design of target prioritization pipelines to select cancer dependency genes and corresponding dependent cancer cell lines for inclusion in the DepSHOCK project. Performing CRISPR-based individual gene knock-out experiments on human cancer cell lines with viability readouts as well as longitudinal bulk RNA-sequencing readouts .Performing CRISPRscreens with transcriptomic readouts at single-cell resolution and pre-processing of resulting data. Generating novel scientific hypotheses, interpreting results, writing scientific manuscripts, and disseminating findings through participation in conferences and scientific meetings.A PhD degree in a relevant subject, e.g., molecular biology, biotechnology, genetics, biochemistry, or in a related field of the life sciences. Experience with functional genomics & genetic perturbation techniques including delivery methods, i.e. transfection / transduction / electroporation.Experience with siRNA, shRNA, antisense oligonucleotides and similar technologies. Knowledge of plasmid vector design to perform gain and loss of function studies, experience with bacteria manipulation including liquid and solid culture of bacteria, isolation and transformation, and plasmid DNA extraction.Experience with handling large-scale projects is considered advantageous.Familiarity with 10x single-cell assays is considered advantageous.Ability to interact effectively with other teams and work synergistically to drive projects forward.For any inquiry about the call, please feel free to contact Dr. Francesco Iorio, francesco@humantechnopole1.recruitee.com .HT seeks scientific excellence, we recruit the best scientific talents through international, open calls. Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.Human Technopole is a new international research institute focused on life sciences, located at the heart of MIND Milano Innovation District. Our overarching mission is to improve human health and well-being by carrying out research in life sciences to develop novel approaches in preventive and personalised medicine. HT will train the next generation of leading scientists, and by setting up scientific services and facilities equipped with cutting-edge technology and scientific expertise, the institute will be at service to the national and international scientific community, promoting innovation and progress through technology transfer. Once fully operational, HT will employ over 1.000 scientists from all over the world. At Human Technopole we offer the opportunity to be part of a new, dynamic research institute promoting a highly collaborative and international working environment. We aim to attract the best resources in each field with a selection based on merit and transparency as we believe that highly diverse teams produce the best and most innovative results. If you are a passionate person who likes to seize great challenges, consider applying for one of our scientific or administrative
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