As a rescue intervention for multiple sclerosis (MS), hematopoietic stem cell transplant (HSCT) is being offered with greater frequency.
With only one completed randomized trial available, HSCT remains experimental, but the number of patients treated with this approach has now reached substantial numbers over 20 years of experience at multiple centers, according to two representative real-world studies presented at thethat found HSCT , which is a one-time intervention, to be relatively well tolerated and more effective than disease-modifying therapy for median time to progression in patients refractory to DMT.
In addition, MRI-free activity survival was 88.2% and 78.8% at 2 and 5 years, respectively, Dr Muraro said. "In this real-world cohort, stem cell transplant led to a durable remission of inflammatory activity and to clinical stability even though this included patients with a high EDSS at baseline and a substantial proportion with progressive disease," Dr Muraro said.
Ultimately, he speculated that HSCT, once accepted as a mainstream option for MS, will probably be confined to the 5%-10% of patients with very aggressive disease. This is not for lack of safety or efficacy, but he sees several barriers to using this approach first-line, outside of special situations.
Transplantation Of Hematopoietic Stem Cells Hematopoietic Stem Cell Transplant Stem Cell Transplantation Stem Cell Therapy Stem Cell Haematopoietic Stem Cell Transplant HSCT Hematopoietic Stem Cell Transplantation (HSCT) Haematopoietic Stem Cell Transplantation (HSCT) HSCT - Hematopoietic Stem Cell Transplantation
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