People with type 2 diabetes who regularly use the supplement glucosamine have a lower risk for microvascular complications and diabetic nephropathy, a prospective observational study finds.
used daily by about 20% of US and Australian adults to treat osteoarthritis and joint pain , has been shown to reduce the risk for certain diseases, including T2D , and to have a mild glucose-lowering effect.
Researchers evaluated the association between habitual glucosamine use and the risk for three diabetic microvascular complications in people with T2D from the UK Biobank who did not have microvascular complications at the time of enrollment.The primary outcome was the overall incidence of diabetic microvascular complications, defined as a composite measure of the first occurrence of diabetic nephropathy,During a median follow-up period of 12.3 years, 4399 cases of diabetic microvascular complications were recorded, including 2084 cases of nephropathy, 2401 cases of retinopathy, and 831 cases of neuropathy. Glucosamine use was associated with lower risks for composite microvascular complications and diabetic nephropathy in fully adjusted models. No significant inverse association was found between glucosamine use and the risk for diabetic retinopathy or diabetic neuropathy .“Integrating glucosamine into patient care may help reduce the risk of microvascular complications, thereby improving overall health outcomes,” the authors wrote.This study was led by Zi-Jian Cheng, Center for Genetic Epidemiology and Genomics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China. It was publishedThe UK Biobank did not collect detailed information on glucosamine use, such as the dose and duration of use or data on the side effects of glucosamine consumption. Cases of diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy were identified from hospital records and national death registries, which may have missed some patients with microvascular complications. Furthermore, distinguishing the effects of a healthy lifestyle from those of regular supplement use was difficult due to the observational nature of this study.This study was supported by the Natural Science Foundation of China, Science and Technology Project of Suzhou, and Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University. The authors reported having no relevant conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.All material on this website is protected by copyright, Copyright © 1994-2025 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
Diabetic Nephropathy Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Diabetic Retinopathy Neuropathy Retinopathy Retinal Disease Arthralgia Painful Joint Joint Pain Diabetic Neuropathy Diabetic Neuropathies Diabetic Nerve Damage Pain
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