For patients with sepsis caused by carbapenem-resistant Gram-negative bacteria, a fixed polymyxin B loading dose of 150 mg followed by a maintenance dose of 75 mg every 12 hours is safe, with better 180-day survival, finds a study in Crit_Care.
]. Patients were administered polymyxin B for at least 7 days or until either discharge or death. Except for polymyxin B, doctors could choose one or two anti-infective agents for combination therapy , according to bacterial drug resistance. Patients with clinical signs of infection were sampled every 72 h until two consecutive negative results were obtained.
]: hemodynamic stability in patients with shock , the improved or stable ratio of arterial partial pressure of oxygen/fraction of inspired oxygen for patients with pneumonia, microbiological cure for patients with bacteremia , and improved or stable Sequential Organ Failure Assessment score. or quartile was used to describe the baseline characteristics of continuous variables, and the percentage was used for descriptive analysis of counting variables.
The primary endpoints of patients lost to follow-up were deemed ineffective. A log-rank test was used to compare time-to-event endpoints, and patients without an event were censored up to the date last known to be at risk; also, Kaplan–Meier estimation was carried out. A chi-square test was used to examine the binary endpoints. For the risk difference and relative risk, Wald and Newcombe confidence intervals were offered, respectively.
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