Officers are currently searching for the pair and anyone with information on their whereabouts is asked to get in touch.
Niamh Quigley, 12, and Caileigh Ogilvie, 13, were reported missing from the area on Friday and were seen on Hamilton Road in the town around 9.30pm on Saturday.
A spokesperson for Police Scotland said: "Anyone with information on the whereabouts of Niamh or Caileigh is urged to contact Police Scotland on 101 quoting reference 4219 or 4427 of 4 November, 2022."Glasgow commuters facing disruption on Monday despite strike cancellationMan seriously injured after being struck by car while crossing M8 carriageway
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