A New Hampshire man has become the first to successfully receive a genetically-edited pig kidney transplant at Massachusetts General Hospital. The surgery offers hope for easing the growing shortage of human organs.
Surgeons at Massachusetts General Hospital transplanted a genetically-edited pig kidney into 66-year-old Tim Andrews of Concord, N.H. on Jan. 25, 2025.
Doctors are moving from those one-off experiments to more formal studies. As they monitor Andrews’ recovery, doctors at Mass General Brigham have Food and Drug Administration permission to perform two additional transplants in their pilot study, using gene-edited pig kidneys supplied by biotech eGenesis.
“I have seen my mortality and I was ready to fight,” Andrews said. So he asked Mass General if he could get a pig kidney instead. “I told them. ‘Anything, I’ll do anything. You give me a list of things you want me to do and I’ll do it.’” Andrews started physical therapy and returned six months later about 30 pounds lighter and “running down the hallway almost,” Riella recalled. “He was just, you know, a different person,” so they started checking if he’d qualify for the pilot study.Still, Andrews was a little nervous and sought advice from the only other person who knew what a pig kidney transplant was like — the NYU patient, Towana Looney.
“Those are the patients where it really makes sense for them to try something else,” said Montgomery. His hospital is one of two that will be part of United Therapeutics’ clinical trial later this year, which will include similar patients.
XENOTRANSPLANTATION ORGAN TRANSPLANT PIG KIDNEY MEDICAL RESEARCH Dialysis
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