Researchers have recently published FreeDTS -- a shared software package designed to model and study biological membranes at the mesoscale -- the scale 'in between' the larger macro level and smaller micro level.
Researchers have recently published FreeDTS -- a shared software package designed to model and study biological membranes at the mesoscale -- the scale 'in between' the larger macro level and smaller micro level. This software fills an important missing software among the available biomolecular modeling tools and enables modeling and understanding of many different biological processes involving the cellular membranes e.g. cell division.
Membrane shape contains information about the physiological state of the cell and overall health of an organism, so this new tool, with its wide array of applications, will enhance our understanding of cell behavior and open routes for diagnostics of infections and diseases like Parkinsons.
"There are so many questions and bottlenecks to tackle to reach the end goals, that it would be unlikely that we work on exactly the same problems. However, occasional overlap occurs and is a worthwhile cost we pay for advancing the field. Also, he organized a series of workshops where pioneers in the field met to discuss and share their newest findings.
Many diseases are associated with irregular membrane shape and abnormal biomolecular organization, so the study of membranes can help us understand the state of a cell and overall health of an organism. For instance, when a neuron has increased spiking activity, indicating a higher energy demand, the structure of mitochondria, an organelle responsible for generating cellular energy parcels from food , undergoes changes.
Weria continues with a word of caution:"This is probably stretching it a bit far, but possibly, in the future, by imaging for example our mitochondria and leveraging physics-based computer simulations we may be able to say: This person has this disease with this specific genetic deficiency. So, the perspective for computational modelling is rather great -- we are not there yet, but we can see it in the horizon.
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Physicists develop modeling software to study biological membranes at the mesoscaleResearchers at the Niels Bohr Institute, University of Copenhagen and University of Southern Denmark have recently published FreeDTS—a shared software package designed to model and study biological membranes at the mesoscale—the scale 'in between' the larger macro level and smaller micro level.
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