Physical activity could be a modifiable risk factor against inflammatory bowel disease.
Because previous observational studies on the association between physical activity and IBD risk have yielded a wide range of results and conclusions, researchers conducted a systematic review and meta-analysis to estimate the aggregate effect of physical activity on IBD risk across various demographics.
The analysis included three large population-based cohort studies and seven small and large case-control studies from several global regions that were published before April 2023., and 860,992 individuals without IBD. The case-control studies involved 781 patients with CD and 2636 individuals without CD, and 1127 patients with UC and 3752 individuals without UC.
The Grading of Recommendations Assessment, Development and Evaluation approach was used to determine the quality of evidence in the included studies.Individuals with high physical activity levels had a 22% and 38% reduced risk of developing CD in the cohort studies and case-control studies, respectively, compared with individuals with low physical activity levels.
The risk for incident UC was 13% lower in the high vs low physical activity level groups in the cohort studies, but the reduction in the case-control studies did not reach statistical significance. The quality-of-evidence assessment found no serious limitations in the cohort studies but serious limitations in the case-control studies due to a high risk for bias and significant heterogeneity."There could be a role of physical activity as a prevention strategy against developing IBD.
IBD - Inflammatory Bowel Disease IBD Exercise Physical Activity Crohn's Disease Crohn Disease Regional Enteritis Crohn Crohn’S Ulcerative Colitis Ulcerative Colitis (UC) UC - Ulcerative Colitis Meta-Analysis Colitis Grant Hospitals
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