Ruth Wilson doesn’t look sick yet “everywhere hurts all the time” – because her immune system is attacking her own body.
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Researchers say some other critter likely created Chicago's 'rat hole' sidewalk landmarkGut microbiome tests are everywhere. Should you get one?Mistake-filled legal briefs show the limits of relying on AI tools at workBrazil dismantles hundreds of illegal dredges in major Amazon mining crackdownFDA’s top drug regulator resigns after federal officials probe ‘serious concerns’ about his conductUS ice cream makers say they'll stop using artificial dyes by 2028The Dubai chocolate craze is now about much more than barsPope Leo calls for 'deep reflection' about treatment of detained migrants in the United StatesEntre indignación y reclamos de justicia despiden a alcalde asesinado en el occidente de MéxicoTrump presiona a los republicanos para poner fin al cierre de gobierno más largo de la historiaRuth Wilson, who has lupus, nicknamed the disease of 1,000 faces for its variety of symptoms, watches speakers address the crowd at the Walk with Us to Cure Lupus fundraising event, Saturday, Oct. 18, 2025, in New York. Ruth Wilson doesn’t look sick yet “everywhere hurts all the time” – because her immune system is attacking her own body. The Massachusetts woman has lupus, nicknamed the disease of 1,000 faces for its variety of symptoms — one of a rogues’ gallery ofthat affect tens of millions of people and are a big medical mystery. Now researchers are decoding the biology behind these debilitating diseases in hopes of eventually treating the causes, not just the symptoms.It took six years of symptoms — fevers, rashes, pain, swelling and, finally, her kidneys starting to fail — to get diagnosed. Over a decade later, Wilson relies on a handful of pills every morning and a monthly IV treatment to tamp down – not eliminate – a chronic disease that’s often invisible.Ruth Wilson, right, whose lupus took six years to diagnose, sits with her husband, Jim, and their three dogs at their home, Sunday, Jan. 12, 2025, in Littleton, Mass. Ruth Wilson, right, whose lupus took six years to diagnose, sits with her husband, Jim, and their three dogs at their home, Sunday, Jan. 12, 2025, in Littleton, Mass. Ruth Wilson, right, who has lupus, makes pizzas with her husband, Jim, and their children at their home, Sunday, Jan. 12, 2025, in Littleton, Mass. Ruth Wilson, right, who has lupus, makes pizzas with her husband, Jim, and their children at their home, Sunday, Jan. 12, 2025, in Littleton, Mass. Ruth Wilson, who has lupus, prepares dinner with her family at their home, Sunday, Jan. 12, 2025, in Littleton, Mass. Ruth Wilson, who has lupus, prepares dinner with her family at their home, Sunday, Jan. 12, 2025, in Littleton, Mass. Ruth Wilson, who has lupus, takes a rest from her regular 4 a.m. workout at her home, Monday, Jan. 13, 2025, in Littleton, Mass. Ruth Wilson, who has lupus, takes a rest from her regular 4 a.m. workout at her home, Monday, Jan. 13, 2025, in Littleton, Mass. Ruth Wilson, whose lupus took six years to diagnose, starts her morning ritual of supplements and prescription medications before going to work early Monday, Jan. 13, 2025, in Littleton, Mass. Ruth Wilson, whose lupus took six years to diagnose, starts her morning ritual of supplements and prescription medications before going to work early Monday, Jan. 13, 2025, in Littleton, Mass. Ruth Wilson, right, embraces her husband, Jim, before leaving for her monthly lupus-focused IV treatment, Tuesday, Jan. 14, 2025, in Littleton, Mass. Ruth Wilson, right, embraces her husband, Jim, before leaving for her monthly lupus-focused IV treatment, Tuesday, Jan. 14, 2025, in Littleton, Mass. Ruth Wilson looks for a parking spot as she arrives for her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Ruth Wilson looks for a parking spot as she arrives for her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Sometimes healthy people “fake being sick so they don’t have to go to work. We fake being well so that we can continue to do the things that we want to do.” Her daily pain, fatigue and brain fog wax and wane. Worse are “flares,” when symptoms abruptly and markedly worsen. For Wilson, they bring sudden high fevers, legs too swollen to walk, more intense pain. They impact her job at a medical lab and time with her husband, teen son and college-age daughter. Wilson learned too much sunshine is one of her triggers. So a family visit to the beach means lots of sunscreen, a big hat and long sleeves. Whenever a flare strikes, Wilson pricks her finger for a blood sample. It’s part of a study led by the Lupus Research Alliance to better understand the disease’s variations. A tattoo reading “Never Stop Fighting” decorates the arm of Ruth Wilson, as she receives her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. A tattoo reading “Never Stop Fighting” decorates the arm of Ruth Wilson, as she receives her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Ruth Wilson, whose lupus took six years to diagnose, receives her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Ruth Wilson, whose lupus took six years to diagnose, receives her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Ruth Wilson, who has lupus, leaves her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Ruth Wilson, who has lupus, leaves her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Ruth Wilson, left, attends a lupus support group with Dr. Roberto Caricchio, center, director of the Lupus Center at UMass Chan Medical School, and fellow lupus patients Juan Sanchez, from second left, Rekha Sredhara and Frank Camacho, Wednesday, Feb. 12, 2025, in Worcester, Mass. Ruth Wilson, left, attends a lupus support group with Dr. Roberto Caricchio, center, director of the Lupus Center at UMass Chan Medical School, and fellow lupus patients Juan Sanchez, from second left, Rekha Sredhara and Frank Camacho, Wednesday, Feb. 12, 2025, in Worcester, Mass. Ruth Wilson, whose lupus took six years to diagnose, fights back tears while talking about her condition, Sunday, Jan. 12, 2025, during an interview at her home in Littleton, Mass. Ruth Wilson, whose lupus took six years to diagnose, fights back tears while talking about her condition, Sunday, Jan. 12, 2025, during an interview at her home in Littleton, Mass. Ruth Wilson, who has lupus, leaves her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. Ruth Wilson, who has lupus, leaves her monthly lupus-focused IV treatment at UMass Memorial Medical Center, Tuesday, Jan. 14, 2025, in Worcester, Mass. She balances her illness with volunteering to help other patients. One evening, Wilson greeted members of her lupus support group with hugs, commiserating about symptoms and treatments. Then she introduced a guest speaker, her rheumatologist, to discuss experimental therapies and answer questions. It’s important for me to also be a voice for patients because I think of myself, in how lonely I was at the very beginning,”For a long time, “I never wanted to talk about it. Especially my kids, I wanted them to know that I was going to be OK. And so you put on your makeup and your lipstick and your three shades of eye corrector and you go on.” Ruth Wilson, who lives with daily pain and fatigue from her lupus, puts away a bin of supplements and prescription medications she travels with while on vacation, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who lives with daily pain and fatigue from her lupus, puts away a bin of supplements and prescription medications she travels with while on vacation, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who balances her lupus illness with volunteering to help other patients, sits for a portrait, Saturday, Oct. 18, 2025, in New York. Ruth Wilson, who balances her lupus illness with volunteering to help other patients, sits for a portrait, Saturday, Oct. 18, 2025, in New York. Ruth Wilson, who has lupus and is sensitive to the sun, stands at the water’s edge while at the beach with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who has lupus and is sensitive to the sun, stands at the water’s edge while at the beach with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson begins to feel a migraine and fatigue, as too much sunshine is one of her lupus symptom triggers, while at the beach with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson begins to feel a migraine and fatigue, as too much sunshine is one of her lupus symptom triggers, while at the beach with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who has lupus, takes a nap after the onset of a migraine and fatigue, as too much sunshine is one of her triggers, while at the beach with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who has lupus, takes a nap after the onset of a migraine and fatigue, as too much sunshine is one of her triggers, while at the beach with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who has lupus, reacts after missing a putt while playing mini golf on vacation with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who has lupus, reacts after missing a putt while playing mini golf on vacation with family, Saturday, Aug. 16, 2025, in South Yarmouth, Mass. Ruth Wilson, who balances her lupus illness with volunteering to help other patients, puts on makeup as she gets ready for the Walk with Us to Cure Lupus fundraising event, Saturday, Oct. 18, 2025, in New York. Ruth Wilson, who balances her lupus illness with volunteering to help other patients, puts on makeup as she gets ready for the Walk with Us to Cure Lupus fundraising event, Saturday, Oct. 18, 2025, in New York. Ruth Wilson, left, embraces Adrienne Nicole, both whom have lupus, as they bump into each other at the Walk with Us to Cure Lupus fundraising event, Saturday, Oct. 18, 2025, in New York. Ruth Wilson, left, embraces Adrienne Nicole, both whom have lupus, as they bump into each other at the Walk with Us to Cure Lupus fundraising event, Saturday, Oct. 18, 2025, in New York. The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.Neergaard is an Associated Press medical writer who covers research on brain health, infectious diseases, organ transplantation and more. She is based in Washington, D.C.
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