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WASHINGTON - A Pfizer lung cancer drug has been shown to greatly reduce tumor progression and improve survival outcomes for people in the advanced stages of a rare form of the disease, according to trial results published Friday.Lorlatinib, which is already approved and available under the brand name Lorbrena in the United States, was tested in a clinical trial of hundreds of people with anaplastic lymphoma kinase -positive advanced non-small cell lung cancer .
NSCLC accounts for more than 80 percent of lung cancers, with ALK-positive tumors responsible for roughly five percent of NSCLC cases, translating to around 72,000 new cases each year worldwide.ALK-positive NSCLC mostly affects younger patients and is not strongly linked to smoking. It is also very aggressive -- 25-40 percent of people with ALK-positive NSCLC develop brain metastases within the first two years.
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