Personalized repetitive transcranial magnetic stimulation slowed cognitive and functional impairment in a phase 2 study of mild to moderate Alzheimer’s disease.
In a 52-week phase 2 trial, personalized rTMS applied over the precuneus, a core component of the default mode network , slowed the progression of cognitive and functional decline in patients with mild to moderate AD.“These latest results provide new additional evidence...
Personalization of the rTMS treatment was established using single-pulse TMS concurrently in combination with electroencephalography based on the recording, processing, and proprietary analysis of transcranial evoked potentials and patient MRI data.The study showed that personalized rTMS of the precuneus had a significant effect on the primary outcome of change from baseline to week 52 of the Clinical Dementia Rating Scale-Sum of Boxes .
Limitations of the study included the small sample size, single-center design, and lack of cerebrospinal fluid or blood-based biomarkers that would provide evidence for the biological effects of rTMS. The technology has received breakthrough device designation by the US Food and Drug Administration. The researchers plan to launch a pivotal randomized controlled clinical trial in 2025.Reached for comment, Shaheen Lakhan, MD, PhD, neurologist and researcher based in Miami, noted that the “personalized nature of the rTMS intervention in this Alzheimer’s study is a particularly exciting aspect.”
Alzheimer Disease Brain Brain Stimulation Repetitive Transcranial Magnetic Stimulation Rtms - Repetitive Transcranial Magnetic Stimulati Impairment Electrophysiology Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Pain Management Biomarker Biological Marker
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