The magnitude of risk is greater for pregnancies conceived using Assisted Reproductive Technology (IVF, IVF-ICSI) rather than non-ART (ovulation induction, intra-uterine insemination) fertility treatments, finds a study published in BMCPregnancyChildbirth
Crude cumulative incidences of adverse pregnancy and birth outcomes were highest in ART pregnancies . Compared with spontaneously conceived pregnancies, ART pregnancies had significantly increased risks of stillbirth , multiple birth , cesarean delivery , preterm birth , very preterm birth , and low Apgar score . Within 28 days of birth, infants conceived via ART had a significantly increased risk of a diagnosis or procedure in the composite NAOI .
Table 2 Association between fertility treatments and pregnancy and birth outcomes, Ontario, Canada , cesarean delivery , preterm birth , very preterm birth , low Apgar score , and composite NAOI . By contrast, such pregnancies were associated with significantly reduced risks of stillbirth and SGA .The cumulative incidence of NICU admission was higher among infants conceived via ART and via non-ART , compared with spontaneously conceived infants .
Table 3 Association between fertility treatments and pediatric health outcomes, Ontario, Canada and non-ART . We observed small risk reductions for upper respiratory tract infections among non-ART pregnancies , and for otitis media among ART pregnancies . ART pregnancies were significantly associated with complex chronic conditions by age one , while the risk for non-ART pregnancies was significantly reduced . No association with infant mortality emerged for pregnancies via ART or non-ART .
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